Dr Harshit Aggarwal

Amiodarone

Amiodarone  1. CLASSIFICATION  Amiodarone = Class III antiarrhythmic (Vaughan-Williams classification)    2. MECHANISM OF ACTION  K⁺ channel blockade (Phase 3) ↑ repolarization time ↑ QT interval ↑ refractory period → prevents re-entry circuits Na⁺ channel blockade ↓ conduction velocity (especially in ischemic tissue) Ca²⁺ channel blockade ↓ AV node conduction Non-competitive β-blockade ↓ sympathetic drive

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Acute Kidney Injury

Acute Kidney Injury (AKI) AKI is a rapid decline in kidney function (hours to days), resulting in the accumulation of nitrogenous waste, electrolyte imbalance, and dysregulation of volume and acid-base status. Category Definition / Time Course Acute Kidney Injury (AKI) Abrupt decline in kidney function occurring within ≤7 days. KDIGO AKI is identified by an

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Hypersensitivity Pneumonitis

Hypersensitivity Pneumonitis (HP) / Extrinsic Allergic Alveolitis (EAA) Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease (ILD) caused by repeated inhalation of a sensitizing antigen in susceptible individuals, leading to inflammation of: Alveoli Terminal bronchioles Interstitium Unlike asthma, HP primarily affects the alveolar-interstitial compartment rather than the conducting airways. HP may progress from reversible

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Ventilator Associated Pneumonia

Ventilator Associated Pneumonia (VAP)  Pneumonia occurring ≥48 hours after endotracheal intubation and initiation of invasive mechanical ventilation Infection not present or incubating at the time of intubation Related Terms (CDC Surveillance) Term Definition VAP Clinical diagnosis Ventilator-Associated Event (VAE) Surveillance definition VAC Ventilator-associated condition IVAC Infection-related VAC Possible VAP IVAC + microbiology  Exams focus: Clinical

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Fournier’s Gangrene

Fournier’s Gangrene  Fournier’s gangrene (FG) is a rapidly progressive, life-threatening form of necrotizing fasciitis involving the perineum, genitalia, and perianal region. It is characterized by: Necrosis of superficial and deep fascial planes Microvascular thrombosis Extensive tissue destruction Polymicrobial infection Severe sepsis and septic shock Why Is It Dangerous? Mortality remains:20–40% ,Can exceed:70–80% when: Septic shock

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How to Prepare for NEET SS: Why Some People Crack NEET SS and Others Don’t

How to Prepare for NEET SS: Why Some People Crack NEET SS and Others Don’t Before I start, let me establish some credibility.I secured AIR 72 in NEET SS while doing residency. No dedicated one-year study leave. No Himalayan retreat. No disappearing from clinical work. Just residency. So either I got extraordinarily lucky, or I

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How to Choose the Right Branch After MBBS: A Practical Way to Find Your True Interest

Every MBBS student reaches a point where one question starts dominating every conversation: “Which branch should I choose?” Some branches offer money. Some offer prestige. Some offer a relaxed lifestyle. Some are considered “elite.” Some are hyped by coaching culture, seniors, social media, or relatives. And somewhere between all these external influences, many students slowly

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