Anatomical and physiological differences in child vs adult Anesthesia
Anatomical and Physiological Differences: Child vs Adult Children and neonates in particular are not simply small adults. Every organ system undergoes structural and functional maturation over the first years of life, and these differences directly shape anaesthetic risk, airway management, drug dosing, fluid therapy and perioperative monitoring. 1. Body Size, Proportions & Surface Area Parameter
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Huntington’s Disease
Huntington’s Disease (HD) Huntington’s Disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by a CAG trinucleotide repeat expansion in the HTT (IT15) gene on chromosome 4p, leading to toxic polyglutamine accumulation, striatal neuronal loss, chorea, cognitive decline, and progressive motor, cognitive, and behavioral deterioration over roughly 15–20 years. Genetics & Basic Facts ●
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CHRONIC PANCREATITIS
CHRONIC PANCREATITIS At a glance Domain Practical point Definition Progressive fibro-inflammatory pancreatic condition with irreversible structural injury and leading to both exocrine/endocrine dysfunction. Etiology Use TIGAR-O: toxic-metabolic, idiopathic, genetic, autoimmune, recurrent/severe acute pancreatitis, obstructive. Clinical pattern Pain (major presentation) and/or maldigestion; later steatorrhea, weight loss, diabetes, nutritional and bone complications. Diagnosis CT or MRI/MRCP is
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ACUTE PANCREATITIS
ACUTE PANCREATITIS At a glance Domain Practical point Diagnosis (Revised Atlanta Classification 2012) 2 of 3: characteristic upper abdominal pain, Sr. Amylase/lipase ≥3× ULN, or compatible imaging. Etiology Gallstones and alcohol account for about two-thirds of cases; actively assess biliary, alcohol, metabolic, drug, structural and uncommon causes. Severity Persistent organ failure >48 h is the
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Immune Thrombocytopenic Purpura
Immune Thrombocytopenic Purpura (ITP) Definition Immune Thrombocytopenic Purpura (ITP) — also known as Immune Thrombocytopenia — is an acquired autoimmune disorder characterized by isolated thrombocytopenia (platelet count <100,000/µL) It is a diagnosis of exclusion — no other cause of thrombocytopenia should be present. Hematologist Referral is must Classification Type Description Primary ITP Isolated thrombocytopenia without
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Neurogenic Pulmonary Edema
Neurogenic Pulmonary Edema(NPE) Introduction Neurogenic pulmonary edema (NPE) is an acute pulmonary edema syndrome occurring after a severe acute CNS insult, particularly when the neurological event causes an abrupt rise in intracranial pressure and/or massive sympathetic activation. It can be confused with: aspiration pneumonitis cardiogenic pulmonary edema ARDS pneumonia fluid overload pulmonary embolism NPE may
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