Drugs

DIRECT ORAL ANTICOAGULANTS (DOACs) 1. CLASSIFICATION Two classes Class Drug Target Direct thrombin inhibitor Dabigatran Factor IIa (thrombin) Direct factor Xa inhibitors Rivaroxaban Xa Apixaban Xa Edoxaban Xa NOAC = Non-vitamin K antagonist oral anticoagulant.(Older terminology for DOAC) Dabigatran = highly renal dependent → avoid in AKI Apixaban = safest in renal dysfunction 2. Major […]