Neurology

Acute Disseminated Encephalomyelitis (ADEM) Acute disseminated encephalomyelitis (ADEM) is a monophasic (in most cases), immune-mediated, demyelinating disorder of the CNS that classically follows a viral infection or vaccination — characterized by multifocal white and grey matter demyelination with encephalopathy, predominantly affecting children. At a Glance Domain Practical Point Definition CNS demyelinating syndrome, almost always monophasic, […]

Huntington’s Disease (HD) Huntington’s Disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by a CAG trinucleotide repeat expansion in the HTT (IT15) gene on chromosome 4p, leading to toxic polyglutamine accumulation, striatal neuronal loss, chorea, cognitive decline, and progressive motor, cognitive, and behavioral deterioration over roughly 15–20 years. At a Glance Domain Practical