Physiological Changes in Pregnancy and Their Anaesthetic Implications
Physiological Changes in Pregnancy and Their Anaesthetic Implications Physiological adaptation in pregnancy occurs due to three broad mechanisms (Miller’s Anesthesia, 10th ed.): (1) Hormonal changes – oestrogen, progesterone, relaxin, prostaglandins, human placental lactogen, renin–angiotensin–aldosterone activation. (2) Mechanical effects of the enlarging gravid uterus (aortocaval compression, diaphragmatic splinting, altered spinal curvature). (3) Increased maternal metabolic […]
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