🔹 Thrombocytopenia in ICU

• Differential diagnosis: sepsis, drugs (heparin, linezolid), DIC, HIT, TTP
• Heparin-Induced Thrombocytopenia (HIT)
• Immune thrombocytopenic purpura (ITP) 
• Disseminated Intravascular Coagulation (DIC)

🔹 Anemia in Critical Illness

• Anemia of critical illness vs acute blood loss anemia
• Transfusion thresholds (restrictive vs liberal)
• TRALI, TACO
• Massive transfusion protocol (MTP)

🔹 Thrombotic Microangiopathies

• TTP vs HUS

🔹 Venous Thromboembolism (VTE)

• DVT
• Pulmonary Embolism

🔹 Hemato-Oncology in ICU

• Leukostasis in hyperleukocytosis (AML): emergency management
• Tumor lysis syndrome (TLS)
• Febrile neutropenia
• Hemophagocytic lymphohistiocytosis (HLH)
• CAR-T cell therapy complications (CRS, neurotoxicity)

🔹 Bleeding and Coagulation

• Coagulation cascade: ICU relevance
• PT, aPTT, INR interpretation
• Reversal of anticoagulation (warfarin, DOACs)
• Role of PCC, vitamin K, andexanet alfa, idarucizumab
• ROTEM/TEG: viscoelastic testing in bleeding

🔹 Bone Marrow Transplant Patients in ICU

• Common complications: GVHD, infections, SOS/VOD
• Management of neutropenic sepsis
• Engraftment syndrome

🔹 Transfusion Medicine

• PRBC, FFP, cryoprecipitate indications
• Leukoreduction, irradiation, washing of blood products
• Complications: alloimmunization, iron overload, hemolytic reactions

🔹 Immune Dysregulation and Immunosuppression

• Impact of critical illness on immunity
• Secondary immunodeficiency in ICU (chemotherapy, transplant patients)
• Management of infections in asplenic or immunocompromised patients