Amiodarone

Amiodarone  1. CLASSIFICATION  Amiodarone = Class III antiarrhythmic (Vaughan-Williams classification)  2. MECHANISM OF ACTION  K⁺ channel blockade (Phase 3) ↑ repolarization time ↑ QT interval ↑ refractory period → prevents re-entry circuits Na⁺ channel blockade ↓ conduction velocity (especially in ischemic tissue) Ca²⁺ channel blockade ↓ AV node conduction Non-competitive β-blockade ↓ sympathetic drive  3.

Amiodarone Read More »

Acute Kidney Injury

Acute Kidney Injury (AKI)  KDIGO Definition of AKI AKI is diagnosed if any one of the following is present: Increase in Serum Creatinine-≥0.3 mg/dL (26.5 μmol/L) within 48 hours Relative Increase in Creatinine-≥1.5 times baseline within previous 7 days Reduced Urine Output—<0.5 mL/kg/hr for 6 hours KDIGO Staging of AKI Stage Serum Creatinine Criteria Urine

Acute Kidney Injury Read More »

Hypersensitivity Pneumonitis

Hypersensitivity Pneumonitis (HP) / Extrinsic Allergic Alveolitis (EAA) Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease (ILD) caused by repeated inhalation of a sensitizing antigen in susceptible individuals, leading to inflammation of: Alveoli Terminal bronchioles Interstitium Unlike asthma, HP primarily affects the alveolar-interstitial compartment rather than the conducting airways. HP may progress from reversible

Hypersensitivity Pneumonitis Read More »

Ventilator Associated Pneumonia

Ventilator Associated Pneumonia (VAP)  Pneumonia occurring ≥48 hours after endotracheal intubation and initiation of invasive mechanical ventilation Infection not present or incubating at the time of intubation Related Terms (CDC Surveillance) Term Definition VAP Clinical diagnosis Ventilator-Associated Event (VAE) Surveillance definition VAC Ventilator-associated condition IVAC Infection-related VAC Possible VAP IVAC + microbiology  Exams focus: Clinical

Ventilator Associated Pneumonia Read More »

Fournier’s Gangrene

Fournier’s Gangrene  Fournier’s gangrene (FG) is a rapidly progressive, life-threatening form of necrotizing fasciitis involving the perineum, genitalia, and perianal region. It is characterized by: Necrosis of superficial and deep fascial planes Microvascular thrombosis Extensive tissue destruction Polymicrobial infection Severe sepsis and septic shock Why Is It Dangerous? Mortality remains:20–40% ,Can exceed:70–80% when: Septic shock

Fournier’s Gangrene Read More »

How to Prepare for NEET SS: Why Some People Crack NEET SS and Others Don’t

How to Prepare for NEET SS: Why Some People Crack NEET SS and Others Don’t Before I start, let me establish some credibility.I secured AIR 72 in NEET SS while doing residency. No dedicated one-year study leave. No Himalayan retreat. No disappearing from clinical work. Just residency. So either I got extraordinarily lucky, or I

How to Prepare for NEET SS: Why Some People Crack NEET SS and Others Don’t Read More »

How to Choose the Right Branch After MBBS: A Practical Way to Find Your True Interest

Every MBBS student reaches a point where one question starts dominating every conversation: “Which branch should I choose?” Some branches offer money. Some offer prestige. Some offer a relaxed lifestyle. Some are considered “elite.” Some are hyped by coaching culture, seniors, social media, or relatives. And somewhere between all these external influences, many students slowly

How to Choose the Right Branch After MBBS: A Practical Way to Find Your True Interest Read More »