Hematology Topics
1️⃣ Approach to Anemia
A. Microcytic Anemia
- Iron deficiency anemia
- Anemia of chronic disease
- Thalassemia
- Sideroblastic anemia
- Lead poisoning
B. Normocytic Anemia
- Acute blood loss
- Hemolysis
- Aplastic anemia
- CKD-related anemia
- Marrow infiltration
C. Macrocytic Anemia
- B12 deficiency
- Folate deficiency
- Alcohol
- Liver disease
- Hypothyroidism
- Myelodysplastic syndrome
2️⃣ Hemolytic Anemia
A. Inherited
- Hereditary spherocytosis
- G6PD deficiency
- Sickle cell disease
- Thalassemia
- PNH
B. Acquired
- Autoimmune hemolytic anemia
- MAHA (TTP, HUS, DIC)
- Mechanical hemolysis
- Drug-induced
3️⃣ Hemoglobinopathies
- Sickle cell crisis types
- Thalassemia major vs trait
- Iron overload management
- Indications for transfusion
4️⃣ Bone Marrow Failure Syndromes
- Aplastic anemia
- Myelodysplastic syndrome
- Myelofibrosis
5️⃣ Leukemia
Acute Leukemias
- AML
- APL
- ALL
Chronic Leukemias
- CML
- CLL
6️⃣ Lymphoma
Hodgkin Lymphoma
4
Non-Hodgkin Lymphoma
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Burkitt lymphoma
7️⃣ Plasma Cell Disorders
- Multiple Myeloma
4
8️⃣ Coagulation Disorders
A. Inherited
- Hemophilia A & B
- von Willebrand disease
B. Acquired
- DIC
- Liver disease
- Vitamin K deficiency
C. Anticoagulation
- Warfarin
- DOAC
- Heparin-induced thrombocytopenia
9️⃣ Platelet Disorders
- ITP
- TTP
- HUS
- Drug-induced thrombocytopenia
- Hypersplenism
🔟 Transfusion Medicine
- Indications for RBC transfusion
- Massive transfusion protocol
- TRALI vs TACO
- Hemolytic transfusion reaction
1️⃣1️⃣ Thrombosis & Hypercoagulability
- Antiphospholipid syndrome
- Factor V Leiden
- Protein C/S deficiency
- DVT