INDEX

🔹 Sepsis and Septic Shock

  • Gram-positive vs gram-negative bacteremia
  • Primary vs secondary bloodstream infections
  • Sepsis

🔹 Antibiotic Stewardship

  • Empiric vs targeted therapy
  • De-escalation strategy
  • Antibiotic dosing in AKI, CRRT, ECMO
  • Time-dependent vs concentration-dependent antibiotics
  • MIC and PK/PD principles
  • Role of procalcitonin and CRP in antibiotic decisions

🔹 Common ICU Infections

  • Ventilator-associated pneumonia (VAP)
  • Central line-associated bloodstream infections (CLABSI)
  • Catheter-associated UTI (CAUTI)
  • Surgical site infections (SSI)
  • Cellulitis with sepsis
  • Necrotizing fasciitis
  • Gas gangrene
  • Pyomyositis
  • Septic arthritis
  • Osteomyelitis with sepsis
  • Toxic Shock Syndrome

🔹 Multidrug-Resistant Organisms (MDROs)

  • ESBL, CRE, MRSA, VRE: identification and treatment
  • Colistin: pharmacology, nephrotoxicity, dosing
  • Novel agents: ceftazidime-avibactam, meropenem-vaborbactam

🔹 Fungal Infections in ICU

  • Candidiasis
  • Aspergillosis
  • Mucormycosis

🔹 Viral Infections in ICU

  • COVID-19
  • HSV
  • CMV 
  • Influenza
  • Viral hemorrhagic fevers

🔹 Immunocompromised Hosts

  • Febrile neutropenia
  • PCP
  • Toxoplasmosis
  • TB reactivation
  • Prophylactic antimicrobials in transplant/oncology patients
  • Infection control measures

🔹 Tropical and Zoonotic Infections

  • Malaria
  • Scrub typhus
  • Leptospirosis
  • Dengue
  • Enteric fever
  • Brucellosis
  • Rickettsial diseases
  • Kala Azar

🔹 Meningitis and Encephalitis

  • Bacterial meningitis
  • Viral encephalitis
  • TB meningitis
  • Brain abscess

🔹 Nosocomial endocarditis in ICU (catheter-associated)

🔹 Infection Control in ICU

  • Hand hygiene, contact precautions
  • Isolation protocols (airborne, droplet)
  • Environmental cleaning
  • Surveillance cultures and infection audits

🔹 Vaccination in ICU Settings

  • Role in immunocompromised patients and healthcare workers
  • Tetanus, rabies, pneumococcus, influenza